Perimenopause (also referred to as premenopause) is the hormonal transition period before the menopause, during which the production of oestrogen and progesterone begins to fluctuate and then decline. (1) These variations influence the menstrual cycle, ovulation, sleep, mood, and physical comfort.
These words are often used premenopause, perimenopause and menopause as if they meant the same thing, but they refer to three different stages in a woman's hormonal life.
Premenopause corresponds to the period when a woman still has regular cycles and normal fertility, before any clear changes related to menopause.
Perimenopause is the transition phase: cycles become irregular, hormonal symptoms appear (hot flushes, sleep disturbances, mood changes, etc.), but periods are still present.
The menopause marks the permanent cessation of periods for 12 consecutive months, with low and stable hormonal production (2).
This phase can begin as early as 35 or 40 years of age in some women, sometimes later. It lasts several years (on average 4 years, often between 2 and 10 years) before the complete cessation of periods and the onset of menopause (defined as 12 consecutive months without periods). During this time, the body does not function in a linear way: cycles become irregular (shorter, longer, sometimes absent for several months), hormonal symptoms appear gradually, and some women notice marked changes in their energy, mood, or sleep (3).
When this transition begins before the age of 40, it is referred to as early premenopause. It remains uncommon but can occur, particularly in cases of family predisposition.
To confirm that this is indeed a hormonal transition, a doctor can measure two hormones: FSH and AMH.
- FSH (Follicle-stimulating hormone): it is a hormone produced by the pituitary gland, located in the brain. Its role is to stimulate the ovaries to mature a follicle in preparation for ovulation. When the ovaries respond less effectively, the brain increases FSH levels to stimulate them. This is why higher FSH levels are observed during perimenopause and menopause.
- AMH (Anti‑Müllerian hormone): it is produced directly by the follicles and therefore reflects the residual follicular reserve. A low AMH indicates a likely end to fertility.
These tests are not routine, but they help to distinguish between a simple cycle irregularity and the beginning of perimenopause or early menopause, particularly in cases of unintended pregnancy, a desire to conceive, or very pronounced symptoms.