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L’impact de la nutrition sur la fertilité

The impact of nutrition on fertility

What impact does nutrition have on fertility? How does nutrition affect hormonal balance? Egg quality? What nutrients are involved?

Contents

Studies have shown that nutrition plays an important role in fertility. Things are often more complex, and many other factors come into play during conception.
While some things are beyond our control, we can view our diet as an important key to our feminine health, and a way of reclaiming some agency. A healthy diet will of course not be able to replace a lifestyle that is incompatible with fertility (stress, exposure to endocrine disruptors, lack of sleep, smoking…).

Take care mama

Trying to conceive is not always straightforward, particularly when the cause of infertility is unexplained. While there are many factors that are difficult to influence, nutrition is a key element of fertility. Through nutrition, you can regain a degree of control over your chances of conceiving!

What is the link between nutrition and fertility?

This is an often overlooked factor. Inadequate nutrition may be a contributing factor to infertility in 46% of cases (far more than other factors such as body weight or physical activity) [1],[2].

Similarly, a dietary intake of polyunsaturated omega-3 fatty acids, alpha-linolenic acid and docosahexaenoic acid (DHA) may have a positive impact on women who have undergone IVF/ICSI [3]. Omega Mama is our supplement omega 3 pregnancy vegan, rich in DHA. 

A study was also able to show that couples who ate more seafood became pregnant sooner than those who rarely consumed it [4].

Why this product?

Choosing the right nutrients during the conception period plays a major role in fertility. Our Baby Bump supplement contains folates, vitamins B6, B12 and D in bioavailable forms, all of which contribute to the mechanisms that may affect fertility.

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How important is nutrition for hormonal balance?

Everything that makes up our bodies, including hormones, is built from what we eat and absorb. Food is therefore the raw material for our hormones and is essential for hormonal balance.

Moreover, food provides us with the vitamins, minerals and phytonutrients that act as the "fuel" for all the chemical reactions taking place every second in our bodies — including those required for the menstrual cycle and fertility.

Finally, hormonal balance often goes hand in hand with a healthy libido (a low libido is frequently a sign of hormonal imbalance), which is helpful when you are trying to conceive!

How can you practically optimise your hormonal balance?
Start by avoiding inflammatory foods, stock up on nutrients, and take care of your liver!

Avoid refined sugar
 

Whether in the form of sweets, pastries, fizzy drinks, refined cereals… By disrupting blood sugar levels, refined sugar creates inflammation, which is the breeding ground for hormonal imbalances. Inflammation also contributes to the decline of ovarian reserve.


Eat brown rice and potatoes, which mainly contain glucose and little fructose. Glucose is thought to have less of an effect on insulin resistance than fructose.
 

The consumption of sugary drinks (particularly fizzy drinks) has been associated with lower fertility in both men and women [5].

Avoid processed foods
 

They often contain additives, endocrine disruptors, hydrogenated fats and refined sugar, which contribute to hormonal imbalances, and are frequently low in the micronutrients (vitamins, minerals, phytonutrients) needed to support fertility and overall health.

Avoid alcohol, which is inflammatory like sugar
 

It negatively affects the liver, which is a key organ for hormonal balance; it increases circulating oestrogen (one glass of alcohol can raise circulating oestrogen levels by 10%!); it impairs the absorption of B vitamins, which are essential for oestrogen and progesterone balance… and it is harmful for the baby. Not to mention that alcohol is pure sugar. Furthermore, alcohol consumption leads to fewer eggs, poorer egg quality, lower fertilisation rates, poorer sperm quality, and an increased risk of miscarriage…

Avoid large fish
 

Avoid large fish (such as tuna) and other sources of heavy metal exposure, which can disrupt hormones, affect fertility and contribute to negative pregnancy test

Eat organic as much as possible
 

To avoid synthetic pesticides, which act as endocrine disruptors, and to maximise the micronutrient content of food.
The higher the quality of the ingredients, the richer they are in micronutrients, and the fewer potentially harmful substances they contain. This is particularly true of animal products, where quality is especially important.

Make the most of fruits and vegetables
 

Favour the most colourful fruits and vegetables. It is antioxidants that are responsible for the colour in plants, and antioxidants help calm inflammation. For example, choose a red onion over a white one.

A 2018 study found that a dietary change towards more fruit and vegetables and legumes, and less red meat, could increase the chances of conceiving and giving birth to a baby following a course of IVF/ART journey. Among women under 35, an increase of 5 points in their diet towards a Mediterranean pattern ("MedDietScore") was associated with a 2.7-fold increase in the likelihood of conceiving and giving birth to a healthy baby [6].

A study of 5,628 women with low-risk pregnancies found that those who consumed large amounts of fast food and little fruit took longer on average to conceive than those following a balanced diet [7]. Women who did not eat fast food reduced their risk of infertility by 41% (p< 0.001).

Eat leafy green vegetables once a day
 

Green vegetables are highly alkalising and help regulate blood sugar levels. They contain significant amounts of magnesium, potassium, bioflavonoids, folates, fibre, and phytonutrients — all nutrients that are essential for hormonal balance and fertility. 


Vegetables from the brassica family, such as cabbage, Brussels sprouts and broccoli, contain indole-3-carbinol, which promotes beneficial oestrogen metabolites over harmful ones.

Eat bitter vegetables
 

They stimulate the liver. By producing more bile, the liver is supported in its detoxification functions, which are essential for hormone metabolism and therefore hormonal balance — and consequently for supporting fertility.

Drink water
 

Drink 1.5 to 2 litres of water per day to avoid dehydration and support elimination.

Don't be afraid of healthy fats, especially omega-3s!
 

Healthy fats are the primary raw material for the production of sex hormones in particular. They reduce inflammation and support hormonal balance. They are also important for egg quality, embryo morphology, and the development of the central nervous system in the child.

You can find them in small oily fish, avocados, olive oil, seeds, and nuts…

Ensure adequate iodine intake
 

Iodine plays a key role in fertility, as it protects the ovaries and is essential for thyroid function, which is itself crucial for fertility, implantation, and the baby's brain development. A word of caution: too much iodine can disrupt thyroid function, just as too little can — so do not supplement without guidance from a healthcare professional. That said, do not hesitate to include seafood in your diet, such as small oily fish and seaweed.

Ensure adequate zinc levels
 

Essential for egg quality, hormonal balance, liver function, neuroplasticity, memory and learning abilities in children. 
 

You can find it in seafood, meat, pumpkin seeds…

Don't forget magnesium
 

Magnesium plays a key role in hormonal balance, as it is essential for liver function and helps regulate our hormones: progesterone, oestrogen and testosterone. It also regulates cortisol, the stress hormone, as well as cholesterol, which has an effect on reproductive hormones. It is also important for the adrenal glands and for blood sugar/metabolic regulation. 


Beyond the fact that the magnesium content of our food has dropped drastically compared to a few decades ago, most people do not consume enough magnesium-rich foods, and many factors can deplete our reserves — such as stress, exposure to heavy metals, consumption of fizzy drinks or refined/processed products, sweating, and sugar intake (we need 54 molecules of magnesium to metabolise just 1 molecule of sugar)...

Discover our magnesium pregnancy Mama-gnésium. It contains 100% magnesium bisglycinate, the form best absorbed by the body, with no digestive discomfort. 

Stabilise blood sugar levels 
 

Blood sugar balance is the cornerstone of hormonal health. A few tips to help stabilise it:
Favour a low glycaemic index diet
Opt for gentle cooking methods such as steaming, or eat more food raw (cooking contributes to raising blood sugar levels)
Eat foods rich in fibre, which slow the release of sugar into the bloodstream (vegetables, legumes, nuts and seeds, whole fruit, wholegrains...)
Include protein and healthy fats at every meal (which help maintain blood sugar levels)
Avoid snacking throughout the day
Get moving: gentle physical activity such as walking can help regulate blood sugar levels

Did you know?

Inadequate nutrition may be a factor in infertility in 46% of cases…

A few tips

Eat organic as much as possible
Avoid alcohol, sugar and processed/refined products
Eat a variety of fruits and vegetables
Consume enough omega-3 (DHA)
Eat quality protein at every meal
Exercise
Take supplements, particularly B9 and magnesium

What is the link between nutrition and cervical mucus?

Adequate nutrition can help improve the quality and quantity of cervical mucus, which is crucial for achieving a positive pregnancy test. Indeed, without good-quality cervical mucus, the female reproductive system is hostile to sperm, which cannot survive in such an environment.

Generally speaking, good-quality cervical mucus reflects hormonal balance — in particular, sufficient oestrogen production, which supports its production. All the advice mentioned above will therefore be beneficial in this regard, but here are a few additional tips.

Vitamin C contributes to (among other things!) the production of cervical mucus
Sources of vitamin C: citrus fruits, green vegetables, peppers, red berries, melon, tomatoes, broccoli, potatoes, parsley, kiwi… If needed, you may consider taking a vitamin C supplement.

Omega-3s increase cervical mucus.

Discover our products

What is the link between nutrition and egg quality?

The egg of the current cycle reflects our health from 3 months ago. It takes around a hundred days for the dominant follicle to reach ovulation. Its health therefore depends on what happened during that fairly long period. The same applies to men: the sperm released today were formed during the preceding 3 months or so.


Good nutrition will improve the quality of eggs by protecting them from pollutants, and by contributing to the fluidity of their membrane, enabling fertilisation, and sperm quality by supporting good motility and flawless morphology. 

The lipids play a very important role in the composition and fluidity of oocyte membranes (which make it easier for sperm to penetrate the egg). Omega-3s make up the membranes of every cell in the body.

But be careful — not all lipids are equal! High consumption of saturated reduces the number of mature oocytes, as does high consumption of polyunsaturated can impact embryo quality [8].

On the other hand, a high intake of monounsaturated would be beneficial. One study was able to show that obtaining 2% of caloric intake from saturated fats instead of monounsaturated fats was associated with a doubled risk of anovulation [8].

 Sources of healthy fats:

Cold-pressed vegetable oils (such as linseed, camelina or hemp) - Camelina ranks just behind linseed oil for its omega-3 content! Take care with the storage of particularly fragile oils such as linseed oil: keep it in the fridge, as room temperature and natural light can rapidly oxidise the fatty acids and make them harmful. 

Small oily fish (such as sardines or mackerel, less contaminated by heavy metals than salmon) and schizochytrium oil (or our pre and postnatal squares, 200 mg of DHA per square)

Seeds (linseed, chia, pumpkin)

It improves the quality of both eggs and sperm and supports the elimination of heavy metals (thereby protecting our gametes). In men: improves sperm quality and sperm motility
Sources of vitamin C: citrus fruits, green vegetables, peppers, berries, melon, tomato, broccoli, potatoes, parsley, kiwi…

It improves the quality of both eggs and sperm, ovarian function, and follicle development. Choose our vitamin D pregnancy Sunny Mummy if needed. 

Sources: the flesh of oily fish, liver oils, eggs and dairy products.

It helps to eliminate heavy metals such as mercury and lead (which are particularly harmful to sperm and eggs) and supports fertility through its antioxidant role.
Sources: Found in many foods. Just 1 Brazil nut a day is enough to meet your daily requirements.

It improves egg quality. In men, zinc in particular supports the strength of the sperm head to facilitate its penetration of the egg.
Sources: The best sources of zinc (shellfish, liver, pulses, wholegrains such as lentils) are not commonly consumed.
Caution if supplementing: do not supplement with zinc over the long term as it can lead to copper deficiency. As a general rule: do not self-supplement and seek advice from a healthcare practitioner.

Fertility & nutrition: giving yourself every chance

A guide comprehensive to understanding the role of nutrition in female fertility.
Discover the key nutrients, good habits and pitfalls to avoid to boost your chances of conception.

The impact of nutrition on fertility

Our range of pregnancy food supplement, Baby Bump, Bump essentials, Bump powder, for the conception and pregnancy period, is rich in healthy fats (DHA), vitamin D, selenium and zinc!

Our supplement Ovo+ containing zinc, Coenzyme Q10 and NAC contributes to improving egg quality. 

How important is nutrition for ovulation?

Nutrition plays a role at every stage of conception, including ovulation.

The role of protein consumption on fertility and ovulation is still not well understood. However, it has been widely demonstrated that protein consumption has been associated with dysregulation of steroidogenesis in women affected by PCOS, likely by reducing hyperinsulinaemia. A PCOS supplement based on protein can therefore be a good idea.

One study showed that in healthy women, a diet high in protein, particularly animal protein, was significantly associated with lower testosterone levels, highlighting a possible link between protein consumption and androgen synthesis [9].

Furthermore, a low protein intake has been associated with a higher risk of ovulation problems. This relationship is statistically significant in women aged 32 and over, although the mechanisms behind it are not yet understood [10].

Finally, protein consumption promotes the intake of amino acids that are crucial for hormone metabolism and fertility (choline, methionine…) and for blood sugar regulation, which helps reduce inflammation and thus regulate hormones. 

collagen food supplement can be a good option for increasing protein intake.

In a study of 17,544 women, researchers were able to demonstrate a link between chronic sugar consumption and ovulatory disorders [11].

A high glycaemic load, combined with insulin resistance, responsible for greater production of IGF-1 (insulin-like growth factor-1) and androgens, may lead to oocyte maturation defects [12] and contributes significantly to PCOS which can lead to absent or delayed ovulation as well as amenorrhoea.

A consumption of DHA as a supplement in women has been associated with a lower risk of anovulation [13].

A study from the University of Cambridge showed the link between the consumption of minerals such as magnesium and the risk of anovulation.

Purple power (blueberry) and Choconut power (chocolate hazelnut) are rich in plant proteins, with 5g of protein per serving. 

How to support progesterone production?

After ovulation (luteal phase), the follicle transforms into a corpus luteum, which secretes progesterone. 
The role of progesterone is to maintain the uterine lining that receives the embryo during implantation. 
If not enough progesterone is produced, the egg does not have enough time to make its way through and implant. 
Cycles that are too short result in insufficient progesterone, making it difficult to sustain a pregnancy. Progesterone insufficiency is often responsible for miscarriages. 

Consumption of marine polyunsaturated omega-3s has been associated with a longer luteal phase [14], resulting in higher progesterone concentrations, suggesting the benefits of consuming seafood on ovulation and the menstrual cycle in general.

Under the effect of stress, the hypothalamus reduces the signals it sends to the adrenal glands, which in turn reduce the production of FSH and LH, the two hormones that trigger ovulation. A vicious cycle therefore sets in. Stress can also contribute to a lack of progesterone.
Magnesium plays a vital role in hormonal balance, and supports the production of our hormones progesterone, oestrogen and testosterone. It also regulates cortisol, the stress hormone. Finally, it helps the liver to regulate oestrogen which, when present in excess, can lead to a relative deficiency of progesterone.

They contribute to progesterone production [14]. 

Our prenatal supplement BABY BUMP is rich in DHA but also in vitamin B6.

The link between nutrition and implantation

Good nutrition can help increase the supply of blood, oxygen, and nutrients to the endometrium, and support the rebuilding of endometrial tissue.

A multitude of nutrients are essential for implantation: vitamins B12, E, D, B9, and minerals such as copper, iodine, selenium, and zinc.

A high prostacyclin/thromboxane ratio driven by omega-3s may increase the chances of pregnancy in women with fertility problems by increasing blood flow to the uterus [15].

The importance of nutrition in early pregnancy

From the very start of pregnancy, a wide range of nutrients are required both for the development, health and functions of the placenta — such as vitamins B, C, D, E and the minerals copper, iron, selenium and zinc — and for the baby's development (morphogenesis, organogenesis, development of the nervous system, composition of bones and tissues…) — such as vitamins A, B, D, E and the minerals copper, iron, zinc and iodine…  

Pregnancy, from the very first day, is therefore a process that places very high demands on micronutrients. It is also essential to have an adequate intake, as the body will always prioritise the baby's health over the mother's. Consequently, if deficiencies or insufficiencies are present, the mother may find herself "depleted" of her nutrients and end pregnancy with a very poor nutritional status [16], which will not support a gentle post-partum or milk production. It is also advisable to take a post-partum supplement after birth. 

Two separate studies in women experiencing fertility problems showed that embryo quality measures were improved in women who consumed more fish [17] and more DHA [18], supporting the hypothesis that DHA plays a beneficial role in early pregnancy.

The positive effect of a regular intake of ascorbic acid has been widely described in the scientific literature. It has even been shown that its consumption during pregnancy may stimulate placental/trophoblastic steroidogenesis, a physiological process that supports gestation [19].

It has also been reported that in women experiencing recurrent spontaneous miscarriages due to a luteal phase defect, blood levels of this antioxidant were lower than in women with better reproductive outcomes [20].

The key nutrient for conception and pregnancy: vitamin B9

Folates, or vitamin B9, play an essential role in DNA synthesis, methylation (the transfer of a methyl group to another molecule), and protein synthesis. Folate deficiency can impair this methylation process and lead to an accumulation of homocysteine, thereby triggering excessive oxidative stress reactions.

Vitamin B9 deficiency may also be a possible contributing factor in recurrent miscarriages.
For women planning a pregnancy, routine folic acid supplementation is recommended from 4 weeks before conception until 8 weeks after, at a recommended dose of 400 µg per day [21].

Furthermore, folic acid supplementation has been associated with better-quality embryos, higher chances of becoming pregnant, and a reduced risk of anovulation [22].

Tiina Murto and her colleagues evaluated the various factors affecting women undergoing IVF treatment [23]. They found that hormones were not a good predictor of long-term live birth in women with unexplained infertility. Women's age proved to have the best predictive value (77%) for a future live birth. The results showed that plasma folate was a better predictor of pregnancy outcome after infertility treatment (predictive value of 73%) than hormones.

They also found that infertile women used significantly more folic acid supplements, at 400 to 500 µg/day, and had a higher dietary folate intake than fertile women, which was perceived as a better folate status in infertile women.

These studies do, however, have several limitations. Blood folate status is lower than the levels reported in questionnaires on folate intake, which reduces reliability with a risk of overestimation in self-reporting. Furthermore, the effect of socio-economic factors and lifestyle on the use of folic acid supplements in infertile women has not been well studied.

However, the actual effect of folates on IVF pregnancy outcomes has been difficult to establish. The MTHFR 677T-T polymorphism (where folic acid is not converted into its active form), present in approximately 15% of women, is the most common genetic variation that has been linked to folate status, with a reduction in serum folates and an increase in plasma homocysteine levels. The MTHFR 677T-T genotype has been shown to be a risk factor with regard to spontaneous miscarriage, pre-eclampsia, and placental abruption. It has also been demonstrated that one of the genetic variations in the MTHFR gene was associated with a positive IVF pregnancy outcome.

Therefore, the results suggest that folate may play a significant role in the context of pregnancy outcomes, but that other variables in folate metabolism, in particular genetic variation, may play a more central role. It would therefore be useful to study the genotype of women experiencing infertility, or alternatively to use supplements containing the active form of folate directly, namely 5-methyltetrahydrofolate.

On the other hand, in women carrying the MTHFR 677C-T variant, since folic acid will not be converted into its active form and will lead to a blockage of the folate cycle, studies have demonstrated the beneficial effect of supplementation with a methyl donor (vitamins B2, B6, B9 in active form, and B12) in subfertile couples who had previously failed ART attempts [23].

Folic acid and pregnancy are therefore not truly compatible; it is better to opt for the methylated form.

Animal studies have shown that an adequate intake of methyl donors can reduce the effects of environmental endocrine disruptors. Endocrine disruptors are compounds generally found in cosmetics and cleaning products. They disrupt methylation profiles, such as the methylation of homocysteine by folates. In animal models, it has been observed that plastic products such as bisphenol A (BPA), di-2-ethylhexyl phthalate (DEHP) and dibutyl phthalate (DBP) induced reproductive and metabolic pathologies transmitted across several generations. Epidemiological studies in humans have recently highlighted the presence of BPA, parabens and other organic pollutants in the urine or serum of women experiencing difficulty conceiving and/or affected by early menopause. Experiments in mice showed that methyl donor supplementation restored gene expression and counteracted the effects of BPA [24]. Methyl donors are involved in methylation processes. They recycle homocysteine and generate antioxidants capable of modulating gene-related parameters in connection with vitamins B2 and B3. In a recent clinical study, they demonstrated the efficacy of methyl donor supplementation against the negative effects of the environment in subfertile couples [25]. Indeed, a group of 55 women who had been infertile for three to seven years, with low serum AMH concentrations and having undergone at least two failed IVF attempts, followed a methyl donor supplement regimen for four months. Surprisingly, eight spontaneous conceptions were observed within three months. Therefore, as observed in animal models, an adequate nutritional intake of methyl donors can, at least in part, counteract the environmental metabolic disruptions implicated in ovarian infertility.

BABY BUMP, our prenatal vitamins, provide 400µg of vitamin B9 in methylated form, while also covering all essential nutrient needs to prepare your body for the pregnancy ahead.

Looking for an alternative to folic acid? Opt for our pregnancy gummies LEMON FOLATES, sugar-free and strawberry-flavoured, which also provide vitamin B9 in methylated form. Our pregnancy snacks are also a tasty option.
 

In summary: tips for optimal nutrition


- Eating organic as much as possible
- Avoiding alcohol, sugar and processed/refined products
- Eating a variety of fruits and vegetables every day to benefit from the vitamins, minerals and phytonutrients we need to support fertility
- Not being afraid of healthy fats and getting enough omega-3s (DHA)
- Eating quality protein at every meal
- Optimising your microbiome to better absorb nutrients and reduce toxins 
- Maintaining a healthy weight / staying active
- Too little or too much body fat can contribute to under- or over-secretion of oestrogen, amenorrhoea (absence of periods), an increased risk of miscarriage or pre-eclampsia.
- Supplementing, particularly with B9, magnesium

Given that our soils are becoming depleted of nutrients, that our lifestyle contributes to draining our stores of certain nutrients (stress depletes magnesium and B vitamins, the pill depletes zinc, magnesium and B vitamins…), and that it is preferable not to take any risks when trying to conceive, supplementing before conceiving a baby is recommended.

At a minimum, it is recommended to take vitamin B9 supplements at 400 micrograms per day to prevent neural tube defects in the baby. It has been observed that insufficient or deficient levels of vitamin B9 can lead to congenital malformations of the brain, spine and/or spinal cord, including the well-known spina bifida, which forms by day 28 of pregnancy — in other words, before most women even know they are pregnant…

To give your fertility a boost, our range of food supplement to help conceive will be your ally. Red clover, lady's mantle and the zinc bisglycinate work in synergy on ovulation and fertility.

Source 1 : The Influence of Diet on Fertility and the Implications for Public Health Nutrition in the United States, 2018

Source 2, Source 11 : Diet and lifestyle in the prevention of ovulatory disorder infertility, 2007

Source 3, Source 18 : Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology, 2011

Source 4 : Seafood Intake, Sexual Activity, and Time to Pregnancy, 2018

Source 5 : Intake of Sugar-sweetened Beverages and Fecundability in a North American Preconception Cohort, 2018

Source 6 : Adherence to the Mediterranean diet and IVF success rate among non-obese women attempting fertility, 2018

Source 7 : Pre-pregnancy fast food and fruit intake is associated with time to pregnancy, 2018

Source 8 : Dietary fatty acid intakes and the risk of ovulatory infertility, 2007

Source 9 : Dietary protein intake and reproductive hormones and ovulation: the BioCycle study, 2015

Source 10 : Protein intake and ovulatory infertility, 2008

Source 12 : A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility, 2009

Source 13 : Dietary fat intake and reproductive hormone concentrations and ovulation in regularly menstruating women, 2016

Source 14 : Nutritional Factors in the Etiology of the Premenstrual Tension Syndromes, 1983

Source 15 : Women and Omega-3 Fatty Acids, 2004

Source 16 : Micronutrient deficiencies in pregnancy worldwide: health effects and prevention, 2016

Source 17 : The impact of food intake and social habits on embryo quality and the likelihood of blastocyst formation, 2015

Source 19 : Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells, 2008

Source 20 : Antioxidant defence in recurrent abortion, 2000

Source 21 : Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility, 2008

Source 22 : Murto Tiina. Folate, Hormones and Infertility: Different factors affecting IVF pregnancy outcome, 2014

Source 23 : Cornet D, Amar E, Cohen M, Ménézo Y. Clinical evidence for the importance of 1-carbon cycle support in subfertile couples. Austin J Reprod Med Infertil. (2015) 2:1011

Source 24 : Nutrition and Female Fertility: An Interdependent Correlation, 2019

Source 25 : Supporting the One-Carbon Cycle Restores Ovarian Reserve in Subfertile Women: Absence of Correlation with Urinary Bisphenol A Concentration, 2017

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https://www.frontiersin.org/articles/10.3389/fpubh.2018.00211/full

[2] Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstet Gynecol. (2007) 110:1050–8. doi: 10.1097/01.AOG.0000287293.25465.e1

[3] Hammiche F, Vujkovic M, Wijburg W, de Vries JH, Macklon NS, Laven JS, et al. Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology. Fertility Steril. (2011) 95:1820–3. doi: 10.1016/j.fertnstert.2010.11.021

[4] Audrey J Gaskins, Rajeshwari Sundaram, Germaine M Buck Louis, Jorge E Chavarro, Seafood Intake, Sexual Activity, and Time to Pregnancy, The Journal of Clinical Endocrinology & Metabolism, Volume 103, Issue 7, July 2018, Pages 2680–2688, https://doi.org/10.1210/jc.2018-00385

[5] Hatch, Elizabeth E.a; Wesselink, Amelia K.a; Hahn, Kristen A.a; Michiel, James J.a; Mikkelsen, Ellen M.b; Sorensen, Henrik Toftb; Rothman, Kenneth J.a,c; Wise, Lauren A.a Intake of Sugar-sweetened Beverages and Fecundability in a North American Preconception Cohort, Epidemiology: May 2018 - Volume 29 - Issue 3 - p 369-378 doi: 10.1097/EDE.0000000000000812 10.1097/EDE.0000000000000812

[6] Dimitrios Karayiannis, Meropi D Kontogianni, Christina Mendorou, Minas Mastrominas, Nikos Yiannakouris, Adherence to the Mediterranean diet and IVF success rate among non-obese women attempting fertility, Human Reproduction, Volume 33, Issue 3, March 2018, Pages 494–502, https://doi.org/10.1093/humrep/dey003

[7] Jessica A Grieger, Luke E Grzeskowiak, Tina Bianco-Miotto, Tanja Jankovic-Karasoulos, Lisa J Moran, Rebecca L Wilson, Shalem Y Leemaqz, Lucilla Poston, Lesley McCowan, Louise C Kenny, Jenny Myers, James J Walker, Robert J Norman, Gus A Dekker, Claire T Roberts, Pre-pregnancy fast food and fruit intake is associated with time to pregnancy, Human Reproduction, Volume 33, Issue 6, June 2018, Pages 1063–1070, https://doi.org/10.1093/humrep/dey079

[8] Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Dietary fatty acid intakes and the risk of ovulatory infertility. Am J Clin Nutr. 2007 Jan;85(1):231-7. doi: 10.1093/ajcn/85.1.231. PMID: 17209201. 10.1093/ajcn/85.1.231

[9] Mumford SL, Alohali A, Wactawski-Wende J. Dietary protein intake and reproductive hormones and ovulation: the BioCycle study. Fertility Steril. (2015) 104:e2. doi: 10.1016/j.fertnstert.2015.07.005 https://doi.org/10.1016/j.fertnstert.2015.07.005

[10] Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Protein intake and ovulatory infertility. Am J Obstetr Gynecol. (2008) 198:210 e1–7. doi: 10.1016/j.ajog.2007.06.057

[11] Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstetr Gynecol. (2007) 110:1050–8. doi: 10.1097/01.AOG.0000287293.25465.e1 10.1097/01.AOG.0000287293.25465.e1

[12] Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility. Eur J Clin Nutr. (2009) 63:78–86. doi: 10.1038/sj.ejcn.1602904 10.1038/sj.ejcn.1602904

[13] Mumford SL, Chavarro JE, Zhang C, Perkins NJ, Sjaarda LA, Pollack AZ, Schliep KC, Michels KA, Zarek SM, Plowden TC, Radin RG, Messer LC, Frankel RA, Wactawski-Wende J. Dietary fat intake and reproductive hormone concentrations and ovulation in regularly menstruating women. Am J Clin Nutr. 2016;103(3):868–877. 10.3945/ajcn.115.119321

[14] Abraham, G. E. « Nutritional Factors in the Etiology of the Premenstrual Tension Syndromes ». The Journal of Reproductive Medicine 28, nᵒ7 (July 1983): 446‑64. https://pubmed.ncbi.nlm.nih.gov/6684167/

[15] Saldeen, Pia MD, PhD*; Saldeen, Tom MD, PhD† Women and Omega-3 Fatty Acids, Obstetrical & Gynecological Survey: October 2004 - Volume 59 - Issue 10 - p 722-730 doi: 10.1097/01.ogx.0000140038.70473.96 10.1097/01.ogx.0000140038.70473.96

[16] Gernand AD, Schulze KJ, Stewart CP, West KP Jr, Christian P. Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat Rev Endocrinol. 2016 May;12(5):274-89. doi: 10.1038/nrendo.2016.37. Epub 2016 Apr 1. PMID: 27032981; PMCID: PMC4927329. 10.1038/nrendo.2016.37

[17] Braga DP, Halpern G, Setti AS, Figueira RC, Iaconelli A Jr, Borges E Jr. The impact of food intake and social habits on embryo quality and the likelihood of blastocyst formation. Reprod Biomed Online. 2015;31(1):30–38. 10.1016/j.rbmo.2015.03.007

[18] Hammiche F, Vujkovic M, Wijburg W, de Vries JH, Macklon NS, Laven JS, Steegers-Theunissen RP. Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology. Fertil Steril. 2011;95(5):1820–1823. 10.1016/j.fertnstert.2010.11.021

[19] Wu X, Iguchi T, Itoh N, Okamoto K, Takagi T, Tanaka K, et al. Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells. Endocrinology. (2008) 149:73–83. doi: 10.1210/en.2007-0262 10.1210/en.2007-0262

[20] Vural P, Akgul C, Yildirim A, Canbaz M. Antioxidant defence in recurrent abortion. Clin Chim Acta Int J Clin Chem. (2000) 295:169–77. doi: 10.1016/S0009-8981(99)00255-7 10.1016/s0009-8981(99)00255-7

[21] Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility. Fertility Steril. (2008) 89:668–76. doi: 10.1016/j.fertnstert.2007.03.089 10.1016/j.fertnstert.2007.03.089

[22] Murto Tiina. « Folate, Hormones and Infertility: Different factors affecting IVF pregnancy outcome ». 2014

[23] Cornet D, Amar E, Cohen M, Ménézo Y. Clinical evidence for the importance of 1-carbon cycle support in subfertile couples. Austin J Reprod Med Infertil.(2015) 2:1011.

[24] Silvestris, Erica, Domenica Lovero, et Raffaele Palmirotta. 2019. « Nutrition and Female Fertility: An Interdependent Correlation ». Frontiers in Endocrinology 10 (June): 346. https://doi.org/10.3389/fendo.2019.00346.

[25] Silvestris, Erica, Marc Cohen, Dominique Cornet, Laetitia Jacquesson-Fournols, Patrice Clement, Jacques Chouteau, Marc Schneider, Thierry Besnard, et Yves Ménézo. 2017. « Supporting the One-Carbon Cycle Restores Ovarian Reserve in Subfertile Women: Absence of Correlation with Urinary Bisphenol A Concentration ». BioResearch Open Access 6 (1): 104‑9. https://doi.org/10.1089/biores.2017.0016.

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