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Rôles et bienfaits du magnésium pour la santé

The roles and benefits of magnesium for health

Magnesium is an essential mineral involved in numerous metabolic processes, playing an important role in the physiological functioning of the brain, heart and muscles. More than 70% of French people are deficient in magnesium.
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Magnesium is an essential mineral involved in many metabolic processes, playing an important role in the physiological functioning of the brain, heart and muscles. More than 70% of French people are deficient in magnesium.
STATS

77% of women in France have a suboptimal magnesium intake. 

What are the roles of magnesium?

An essential nutrient for our body

The magnesium is a cofactor in the activation of more than 300 enzymatic processes regulating various reactions in the body, including energy metabolism (by contributing to the breakdown of macronutrients), protein and DNA synthesis, muscle and nerve function, blood sugar levels, and blood pressure control [1]. 

Magnesium can interact with calcium in neurological and muscular metabolic processes. A variation in magnesium levels can disrupt this metabolism, so an optimal intake is essential to ensure it functions properly [2]. 
 

What are the daily requirements?

To support the proper functioning of the body, the reference intake for magnesium is 375 mg/day. 

Magnesium is mainly stored in the bones (60–65%), muscles and soft tissues (34–39%), whilst less than 1% is located in the extracellular space [3]. 

The regulation of magnesium depends on the concerted actions of the intestine, responsible for its absorption from food, the bones, which store it, and the kidneys, which regulate the urinary excretion of magnesium [4].

Magnesium is stored transiently to meet immediate needs but not for the long term [5].

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Magnesium deficiency

Magnesium deficiency: what are the causes?

Several dietary surveys and epidemiological studies conducted in the United States and the European Union have revealed that, on average, people have a dietary magnesium intake below the recommended daily intake. 

This situation is most likely due to increased consumption of processed foods as well as lifestyle factors. It is often suggested that more than 50% of the general population may have marginal magnesium deficiencies [6].

What are the causes?

Stress
Diet
Digestive issues

Magnesium deficiency is partly due to the fact that the soils used for agriculture are increasingly depleted of essential minerals. Over the past 60 years, the magnesium content of fruit and vegetables has decreased by 20 to 30% [7].

Furthermore, the Western diet contains more refined grains and processed foods. It is estimated that 80 to 90% of magnesium is lost during food processing [8].

Magnesium status is strongly linked to stress levels. A stressful situation promotes the excretion of magnesium [9]. Stress can therefore lead to magnesium deficiency (our body uses up all its magnesium when we are stressed), and this deficiency in turn promotes stress — making it a vicious cycle…

Digestive disorders can exacerbate the effects of inadequate magnesium absorption. More specifically, diarrhoea is the result of inadequate water reabsorption along the intestine. 

The water absorbed contains magnesium. If too much water is absorbed, there will be significant magnesium loss, and the occurrence of diarrhoea can thus lead to a magnesium deficiency [10]. Likewise, engaging in intense physical activity promotes the excretion of magnesium through perspiration.

A magnesium deficiency can also be genetic in origin or induced by certain medications [11]. For example, people carrying the HLA B35 gene have poorer magnesium retention in their body [12].

What are the consequences of magnesium deficiency?

An imbalance in magnesium levels in the body (hypomagnesaemia) can lead to undesirable neuromuscular, cardiac, or neurological disorders. Maintaining adequate magnesium levels in the body is therefore very important [13]. It is the key nutrient of a women's food supplement

The vicious cycle of stress and magnesium

There is a link between magnesium deficiency and increased susceptibility to stress-related disorders. Moreover, stress itself can lead to magnesium depletion. This is known as the "vicious cycle of stress". To address this, studies show that increasing magnesium intake reduces stress, and that magnesium supplementation is beneficial in stressed individuals [14]. Magnesium may also help in cases of anxiety. [15]
 

Magnesium and hormonal balance

Magnesium plays a key role in hormonal balance, as it is essential for liver function and helps regulate our hormones: progesterone, oestrogen, and testosterone. It also regulates cortisol, the stress hormone. It is likewise important for the adrenal glands and blood sugar regulation/metabolism.

Some studies have shown that magnesium may significantly reduce the intensity and duration of premenstrual syndrome (mood changes, anxiety, depression, bloating, breast pain, water retention...). [16] [17] This is notably due to its effect on the hormonal imbalance. It can indeed broadly alleviate the symptoms of endometriosis [18], fibroids, and perimenopause in particular. Indeed, it is one of the menopause supplements recommended, in addition to a selection of menopause vitamins complementary.

Magnesium and hair

Stress is one of the factors that can cause or worsen hair loss. By acting on stress levels, magnesium may also have an effect on hair. Its antioxidant action also gives it a role in protecting the cells responsible for hair renewal.

Magnesium and metabolism

Magnesium contributes to lipid metabolism, protein synthesis, and the breakdown of glucose to release energy.

A lack of magnesium could contribute to the development of type 2 diabetes by increasing insulin resistance. A meta-analysis of 8 studies highlighted that magnesium supplementation could be a promising avenue for glycaemic control in diabetic patients [19].


Magnesium and bone health

At bone level, the crystals in a magnesium-deficient bone become larger, making the bone more fragile and susceptible to fractures. Furthermore, magnesium stimulates the proliferation of bone cells, which suggests that magnesium deficiency leads to a reduction in bone formation [20].

Other effects of magnesium deficiency 

Magnesium contributes to the prevention of cardiovascular disease, diabetes, and osteoporosis [21].

It also has an anti-inflammatory effect [22].

It plays an important role in muscle activity: a magnesium deficiency can manifest as cramps and muscle spasms [23]. It may therefore help with leg cramps during pregnancy.

It also plays a role in combating headaches and dizziness.

Low magnesium levels are associated with a wide range of neurological conditions such as migraine, depression, and epilepsy. It plays a role in the mechanisms of learning and memory [24].
 

Low dietary magnesium intake has been associated with the risk of several types of cancer. Epidemiological studies have established a correlation between low magnesium intake and the risk of colon cancer [25]. 

What are the consequences?

Hormonal imbalance
Nervous system imbalance 
Fatigue…

How to maintain sufficient magnesium intake?

Magnesium in your diet 

What foods are rich in magnesium?

Magnesium is found in many foods; here is a list of the main sources:

  • Seaweeds such as wakame (1,110 mg/100g) and Japanese kombu (1,050 mg/100g).
  • Various seeds: pumpkin (592 mg/100g), flaxseed (372 mg/100g), sunflower (364 mg/100g), toasted sesame (348 mg/100g) and chia (335 mg/100g).
  • Nuts and seeds, including Brazil nuts (367 mg/100g), almonds (232 mg/100g), cashews (223 mg/100g), peanuts (193 mg/100g) and hazelnuts (173 mg/100g).
  • Wholegrains, for example rolled oats (148 mg/100g) and cooked quinoa (64 mg/100g).
  • Green vegetables, including spinach (53 mg/100g), kale (39 mg/100g) and peas (31 mg/100g).
  • The richest mineral waters contain an average of 100 mg of magnesium per litre.
  • And chocolate! Including unsweetened cocoa powder (500 mg/100g) and dark chocolate bars with no added sugar (152 mg/100g).
     

How can you absorb magnesium better?

Many dietary factors can affect magnesium absorption. 

For example, among those that hinder absorption we find: high doses of other minerals, certain types of poorly digested fibre, phytate (found in coffee, for example) and oxalate. 

On the other hand, proteins, medium-chain triglycerides and low- or non-digestible carbohydrates (for example, resistant starch, oligosaccharides, inulin) promote the absorption of magnesium [26].

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Should you supplement with magnesium?

Magnesium deficiency: very common

Although this mineral is found in a variety of foods, magnesium deficiency is a real concern. 

The SU.VI.MAX study, which records the dietary intake of the French population, found that 77% of women and 72% of men had magnesium intakes below the recommended nutritional intake.

Most people do not consume enough magnesium-rich foods, and with stress, reserves are quickly depleted. It can therefore be worthwhile to turn to food supplements to meet your needs.
 

Do be cautious about self-supplementation! Before making any decision to take a supplement, remember to seek advice from a healthcare professional.
 

Magnesium deficiency during pregnancy

Pregnancy often results in a magnesium deficiency. The expectant mother's body excretes increasing amounts of magnesium through the kidneys due to metabolic changes, and the baby's magnesium requirements also increase as the pregnancy progresses.

Magnesium may reduce pre-eclampsia through its vasodilatory effect on the vascular system. Studies have shown that magnesium treatment in women at risk of pre-eclampsia reduced that risk by more than 50%, and that there was a trend towards a reduction in maternal mortality [27]. It is recommended to combine taking your pregnancy food supplement with a supplement of magnesium pregnancy as well. 
 

Magnesium deficiency during breastfeeding

The magnesium content of breast milk is not affected by the mother's diet — it remains relatively constant [28]. Our body will draw on its reserves if necessary. For the breastfeeding mother, if your magnesium intake is suboptimal, you are at greater risk of suffering from a magnesium deficiency. 

It is recommended to combine taking your post-partum food supplement with an additional magnesium supplement. 

Which type of magnesium should I take?

Magnesium supplementation can be beneficial in certain cases. But be careful — not all forms of magnesium are equal!

Organic magnesium salts (glycerophosphate, citrate, bisglycinate) are to be preferred, as they have the highest bioavailability, unlike inorganic natural forms (such as oxide), which are poorly absorbed and poorly tolerated (digestive discomfort).
 

To find out more about which type of magnesium to choose, have a look at our article on how to choose your magnesium.    

Discover Mama-gnésium, our magnesium food supplement with 100% magnesium bisglycinate. The form of magnesium that ensures optimal absorption without any discomfort. 

Magnesium and pregnancy: your ally for calm & energy

An ebook comprehensive to understand why your needs increase dramatically during pregnancy.
Discover its key roles, the best sources, and how it helps reduce stress, cramps, and fatigue.

The roles and benefits of magnesium for health

Conclusion

Magnesium is an essential mineral for the proper functioning of your body, at the cerebral, muscular and cardiac levels. Our modern lifestyles mean we are increasingly at risk of magnesium deficiency. To address this deficit, food supplements are often used, and organic forms such as magnesium glycerophosphate are to be preferred. 
 

Be careful not to self-supplement — food supplements are not without risk, as they can interact with other supplements, foods and medications, or may not be suited to your personal situation, not to mention that they need to be carefully chosen and doses adjusted accordingly. It is therefore preferable to seek advice from a healthcare practitioner specialising in nutrition (such as a naturopath or nutritional therapist), particularly if you are pregnant or breastfeeding

Source 1, 6, 13 : Predicting and Testing Bioavailability of Magnesium Supplements, 2019

Source 2, 4, 8, 10, 23 : Magnesium in Man: Implications for Health and Disease, 2015

Source 3, 5, 26 : Intestinal Absorption and Factors Influencing Bioavailability of Magnesium—An Update, 2017

Source 7 : Nutritional Quality of Organic versus Conventional Fruits, Vegetables, and Grains, 2001

Source 9 : Magnesium and Stress, 2011

Source 11 : Drug-Induced Hypomagnesaemia: Scope and Management, 2005

Source 12 : The Variability of Human Red Blood Cell Magnesium Level According to HLA Groups, 1980

Source 14 : Magnesium Status and Stress: The Vicious Circle Concept Revisited, 2020

Source 15 : A synergistic effect of magnesium plus vitamin B6 on premenstrual symptoms, 2000

Source 16 : Effect of Magnesium and Magnesium Plus Vitamin B6 Supplement on the Severity of Premenstrual Syndrome, 2010

Source 17 : Effect of a nutritional supplement on premenstrual symptomatology, 1991

Source 18 : Dairy-Food, Calcium, Magnesium, and Vitamin D Intake and Endometriosis, 2013

Source 19 : Effects of Oral Magnesium Supplementation on Glycaemic Control in Type 2 Diabetes, 2006

Source 20, 21 : Infrared Spectroscopy and Magnesium Content of Bone Mineral in Osteoporotic Women, 1981

Source 22 : Ion Channels and Transporters in Lymphocyte Function and Immunity, 2012

Source 24 : NMDA Receptor Subunit Diversity: Impact on Receptor Properties, Synaptic Plasticity and Disease, 2013

Source 25 : Magnesium Intake in Relation to Risk of Colorectal Cancer in Women, 2005

Source 27 : Magnesium Sulphate and Other Anticonvulsants for Women with Pre-Eclampsia, 2010

Source 28 : La Leche League, n.d.

[1] Blancquaert, Laura, Chris Vervaet, et Wim Derave. 2019. « Predicting and Testing Bioavailability of Magnesium Supplements ». Nutrients 11 (7). 10.3390/nu11071663

[2] Baaij, Jeroen H. F. de, Joost G. J. Hoenderop, et René J. M. Bindels. 2015. « Magnesium in Man: Implications for Health and Disease ». Physiological Reviews 95 (1): 1‑46. 10.1152/physrev.00012.2014

[3] Schuchardt, Jan Philipp, et Andreas Hahn. 2017. « Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update ». Current Nutrition and Food Science 13 (4): 260‑78. 10.2174/1573401313666170427162740

[4] Baaij, Jeroen H. F. de, Joost G. J. Hoenderop, et René J. M. Bindels. 2015. « Magnesium in Man: Implications for Health and Disease ». Physiological Reviews 95 (1): 1‑46. 10.1152/physrev.00012.2014

[5] Schuchardt, Jan Philipp, et Andreas Hahn. 2017. « Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update ». Current Nutrition and Food Science 13 (4): 260‑78. 10.2174/1573401313666170427162740

[6] Blancquaert, Laura, Chris Vervaet, et Wim Derave. 2019. « Predicting and Testing Bioavailability of Magnesium Supplements ». Nutrients 11 (7). https://doi.org/10.3390/nu11071663

[7] Worthington, V. 2001. « Nutritional Quality of Organic versus Conventional Fruits, Vegetables, and Grains ». Journal of Alternative and Complementary Medicine (New York, N.Y.) 7 (2): 161‑73. 10.1089/107555301750164244

[8] Baaij, Jeroen H. F. de, Joost G. J. Hoenderop, et René J. M. Bindels. 2015. « Magnesium in Man: Implications for Health and Disease ». Physiological Reviews 95 (1): 1‑46.

[9] Cuciureanu, Magdalena D., et Robert Vink. 2011. « Magnesium and Stress ». In Magnesium in the Central Nervous System, édité par Robert Vink et Mihai Nechifor. Adelaide (AU): University of Adelaide Press. NBK507250

[10] Baaij, Jeroen H. F. de, Joost G. J. Hoenderop, et René J. M. Bindels. 2015. « Magnesium in Man: Implications for Health and Disease ». Physiological Reviews 95 (1): 1‑46.

[11] Atsmon, Jacob, et Eran Dolev. 2005. « Drug-Induced Hypomagnesaemia: Scope and Management ». Drug Safety 28 (9): 763‑88. 10.2165/00002018-200528090-00003

[12] Henrotte, J. G. 1980. « The Variability of Human Red Blood Cell Magnesium Level According to HLA Groups ». Tissue Antigens 15 (5): 419‑30. 10.1111/j.1399-0039.1980.tb00204.x

[13] Blancquaert, Laura, Chris Vervaet, et Wim Derave. 2019. « Predicting and Testing Bioavailability of Magnesium Supplements ». Nutrients 11 (7). https://doi.org/10.3390/nu11071663

[14] Pickering, Gisèle, André Mazur, Marion Trousselard, Przemyslaw Bienkowski, Natalia Yaltsewa, Mohamed Amessou, Lionel Noah, et Etienne Pouteau. 2020. « Magnesium Status and Stress: The Vicious Circle Concept Revisited ». Nutrients 12 (12). 10.3390/nu12123672

[15] Souza MCD, Walker AF, Robinson P A, & Bolland K. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg Vitamin B₆ for the relief of anxiety-related premenstrual symptoms: A randomized, double-blind, crossover study. Journal of Women's Health & Gender-Based Medicine. 2000;9(2):131-139. doi:10.1089/152460900318623 10.1089/152460900318623

[16] Fathizadeh N, Ebrahimi E, Valiani M, Tavakoli N, Yar MH. Evaluating the Effect of Magnesium and Magnesium Plus Vitamin B6 Supplement on the Severity of Premenstrual Syndrome. Iranian Journal of Nursing and Midwifery Research. 2010;15(1):401-405. PMC3208934

[17] London RS, Bradley L, Chiamori NY. Effect of a nutritional supplement on premenstrual symptomatology in women with premenstrual syndrome: a double-blind longitudinal study. Journal of the American College of Nutrition. 1991;10(5): 494-499. doi: 10.1080/07315724.1991.10718176. 10.1080/07315724.1991.10718176

[18] Harris, Holly R., Jorge E. Chavarro, Susan Malspeis, Walter C. Willett, et Stacey A. Missmer. 2013. « Dairy-Food, Calcium, Magnesium, and Vitamin D Intake and Endometriosis: A Prospective Cohort Study ». American Journal of Epidemiology 177 (5): 420‑30. 10.1093/aje/kws247

[19] Song, Y., K. He, E. B. Levitan, J. E. Manson, et S. Liu. 2006. « Effects of Oral Magnesium Supplementation on Glycaemic Control in Type 2 Diabetes: A Meta-Analysis of Randomized Double-Blind Controlled Trials ». Diabetic Medicine: A Journal of the British Diabetic Association 23 (10): 1050‑56. https://www.ncbi.nlm.nih.gov/books/NBK73264/

[20] Cohen, L., et R. Kitzes. 1981. « Infrared Spectroscopy and Magnesium Content of Bone Mineral in Osteoporotic Women ». Israel Journal of Medical Sciences 17 (12): 1123‑25.

[21] Cohen, L., et R. Kitzes. 1981. « Infrared Spectroscopy and Magnesium Content of Bone Mineral in Osteoporotic Women ». Israel Journal of Medical Sciences 17 (12): 1123‑25.

[22] Feske, Stefan, Edward Y. Skolnik, et Murali Prakriya. 2012. « Ion Channels and Transporters in Lymphocyte Function and Immunity ». Nature Reviews. Immunology 12 (7): 532‑47. 10.1038/nri3233

[23] Baaij, Jeroen H. F. de, Joost G. J. Hoenderop, et René J. M. Bindels. 2015. « Magnesium in Man: Implications for Health and Disease ». Physiological Reviews 95 (1): 1‑46.

[24] Paoletti, Pierre, Camilla Bellone, et Qiang Zhou. 2013. « NMDA Receptor Subunit Diversity: Impact on Receptor Properties, Synaptic Plasticity and Disease ». Nature Reviews. Neuroscience 14 (6): 383‑400. https://doi.org/10.1038/nrn3504

[25] Larsson, Susanna C., Leif Bergkvist, et Alicja Wolk. 2005. « Magnesium Intake in Relation to Risk of Colorectal Cancer in Women ». JAMA 293 (1): 86‑89. 10.1001/jama.293.1.86

[26] Schuchardt, Jan Philipp, et Andreas Hahn. 2017. « Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update ». Current Nutrition and Food Science 13 (4): 260‑78. 10.2174/1573401313666170427162740

[27] Duley, Lelia, A. Metin Gülmezoglu, David J. Henderson-Smart, et Doris Chou. 2010. « Magnesium Sulphate and Other Anticonvulsants for Women with Pre-Eclampsia ». The Cochrane Database of Systematic Reviews, no 11 (novembre): CD000025.

[28] La Leche League

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