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Les effets du gattilier sur le cycle menstruel

The effects of vitex agnus-castus on the menstrual cycle

Praised by some and approached with caution by others due to its hormonal action, vitex agnus-castus has more than interesting properties when it comes to menstrual cycle quality. Its use, like that of all plants, must however follow certain guidelines. 

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Praised by some and feared by others due to its hormonal action, chasteberry has more than interesting properties for menstrual cycle quality. Its use, like that of all plants, should however follow certain guidelines. 
Did you know?

Chasteberry is a plant that influences hormonal balance without containing any hormones! It acts at the level of the gland that regulates hormone production. 

How does chaste tree work?

Vitex (known as gattilier in French) is a plant that influences hormonal balance without containing any hormones. It may be helpful in cases of hormonal imbalance. By acting on the pituitary gland, that small gland in the brain that conducts our hormonal system, it is able to influence the production of LH, the essential hormone for triggering ovulation, and to restore oestrogen and progesterone secretions whilst regulating prolactin.

As is often the case with hormones, the action of vitex is not immediate and it is common to notice effects only after 3 months of use. In naturopathy, it is said that "function creates the organ". It can therefore sometimes be useful to give the body a helping hand, while always allowing it to work on its own as well. This is why it is generally recommended to observe therapeutic windows, that is, breaks between supplementation periods, as here with vitex.

For best results, it is recommended to take it in the morning on an empty stomach, as this is when the pituitary gland is most receptive.

Why this product?

Thewomen's food supplementwith adaptogenic plants, to help rebalance the cycle and relieve associated symptoms.

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What are the properties of chaste tree (vitex)?

Relieving PMS

Premenstrual syndrome is a broad category grouping together certain physical and psychological symptoms that occur before menstruation, such as mood disturbances, a feeling of breast tension, migraines and/or abdominal pain.

By acting in a similar way to certain opioids, it calms the nervous system and helps to relieve pain by releasing endorphins — those well-known neurotransmitters involved in the sensation of pleasure which, like our hormones, drop towards the end of the cycle. There is no need to worry, though: chasteberry is of course not a drug!

Chasteberry also helps to regulate prolactin secretion[1], which can both interfere with ovulation, with progesterone secretion, and contribute to premenstrual breast discomfort[2]. By supporting a healthy oestrogen/progesterone balance, we can address the root cause of PMS — namely an excess of oestrogen dominance in the second half of the cycle.

A German study also examined the very positive results of chasteberry in relieving various aspects of PMS such as irritability, depression, migraines, abdominal pain, and breast tenderness[3].

A food supplement for premenstrual syndrome based on chasteberry may be of interest.

Helps to facilitate ovulation

Chasteberry can help to facilitate ovulation, which is particularly important in cases of long cycles related to PCOS, for example, or in amenorrhoea.

When prolactin, the hormone involved in breastfeeding, is too high (whether or not you are breastfeeding), the body is unable to ovulate, which results in the absence of periods. By acting on the pituitary gland, the gland responsible for prolactin secretion, chasteberry helps to regulate prolactin levels and support the return of regular cycles.

Regulating by calming the nervous system

The other action of chasteberry is to calm the nervous system[4], helping it to return to balance and resolve amenorrhoea linked to stress, for example.

Improving fertility

Many cases of infertility or miscarriage are linked to an insufficient luteal phase, meaning a post-ovulatory phase that is too short, where exposure to progesterone is insufficient to allow the fertilised egg to implant properly.

A study observed the effects of chasteberry in women over 3 months, and demonstrated a reduction in prolactin release, a shortening of luteal phases back towards normal, and also that deficits in luteal progesterone synthesis were eliminated. These changes were significant and occurred only in the treated group[5].

But chasteberry can also help women who do not have hyperprolactinaemia, since following supplementation with chasteberry, maca, B vitamins and omega-3, the number of ovulations was observed to increase from 10 to nearly 43% over 18 months[6].

Finally, due to its ability to occupy certain oestrogen receptors, chasteberry helps to reduce excess oestrogen that can interfere with follicle maturation and ovulation in women, and may improve fertility issues[7].

Chasteberry can be taken alongside our food supplement to support conception

Better managing certain symptoms of PCOS

The Polycystic ovary syndrome is a combination of factors often involving an excess of androgen hormones, insulin resistance, and long cycles linked to difficulties with ovulation.

While the main approach to relieving its symptoms is adopting an appropriate lifestyle, chasteberry may have a positive effect on hirsutism and excess male hormones when these are linked to overproduction of prolactin.

Furthermore, chasteberry may have an effect on the length of the menstrual cycle. In one study, women with irregular menstrual cycles who took a herbal preparation containing chasteberry showed a statistically significant improvement in menstrual cyclicity compared with those who took a placebo[8].

Please be aware, however, that if your PCOS is linked to a poor ratio between your LH and FSH hormones, it is better to look towards another PCOS supplement.

Reducing the risk of fibroids

Chasteberry can notably help to improve the balance between oestrogen and progesterone[9]. Yet one of the main causes of fibroids is precisely this oestrogen dominance. Acting on the root cause of the problem could therefore help to limit the risk of developing them.

Easing period pain in cases of endometriosis

Excess oestrogen is one of the main factors inendometriosis. By improving the capacity for ovulation, chasteberry helps to rebalance the progesterone/oestrogen ratio.

Thanks to the progesterone secreted after ovulation, the nervous system is more settled and muscles are more relaxed. Yet the main cause of pain is in fact the lack of oxygen in the uterine muscle due to excessively repeated contractions. The soothing action of progesterone on tissues is therefore particularly useful for relieving period pain, whether or not it is related to endometriosis.

Premenstrual syndrome

PMS is a broad category encompassing certain physical and psychological symptoms that occur before your period, such as mood disturbances, breast tenderness, migraines and/or abdominal pain.

Vitex and PMS

By acting in a similar way to certain opioids, it calms the nervous system and helps relieve pain by releasing endorphins — those well-known neurotransmitters involved in the sensation of pleasure which, like our hormones, drop towards the end of the cycle. That said, there is no need to worry: chasteberry is of course not a drug!

When should you avoid chasteberry?

Due to its hormonal action, agnus castus is best avoided if you have a history of or a predisposition to hormone-dependent cancers. For the same reason, hormone-like plants should also be avoided during pregnancy and breastfeeding.

Also be cautious if you are taking the pill: vitex agnus-castus may interfere with its efficacy.

Also be mindful if you are on a ART pathway, chasteberry's action may work against treatments or have an additive effect.

Finally, in very rare cases (so rare that very little information exists on the subject), chasteberry may exacerbate a depressive state. If this is the case for you, it is best to stop taking it.

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The effects of vitex agnus-castus on the menstrual cycle
[1] Ooi SL, Watts S, McClean R, Pak SC. Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A Systematic Review and Meta-Analysis. J Womens Health (Larchmt). 2020 Feb;29(2):262-278. doi: 10.1089/jwh.2019.7770. Epub 2019 Aug 29. PMID: 31464546.

[2] Ooi SL, Watts S, McClean R, Pak SC. Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A Systematic Review and Meta-Analysis. J Womens Health (Larchmt). 2020 Feb;29(2):262-278. doi: 10.1089/jwh.2019.7770. Epub 2019 Aug 29. PMID: 31464546.

[3] Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study BMJ 2001; 322:134 doi:10.1136/bmj.322.7279.134

[4] Webster DE, Lu J, Chen SN, Farnsworth NR, Wang ZJ. Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. J Ethnopharmacol. 2006 Jun 30;106(2):216-21. doi: 10.1016/j.jep.2005.12.025. Epub 2006 Jan 24. PMID: 16439081.

[5] Milewicz, A., E. Gejdel, H. Sworen, K. Sienkiewicz, J. Jedrzejak, T. Teucher, et H. Schmitz. 1993. « [Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study] ». Arzneimittel-Forschung 43 (7): 752‑56

[6] Antoine E, Chirila S, Teodorescu C. A Patented Blend Consisting of a Combination of Vitex agnus-castus Extract, Lepidium meyenii (Maca) Extract and Active Folate, a Nutritional Supplement for Improving Fertility in Women. Maedica (Bucur). 2019 Sep;14(3):274-279. doi: 10.26574/maedica.2019.14.3.274. PMID: 31798745; PMCID: PMC6861720.

[7] Rafieian-Kopaei M, Movahedi M. Systematic Review of Premenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus. Electron Physician. 2017;9(1):3685-3689. Published 2017 Jan 25. doi:10.19082/3685

[8] Alois, Marika, et Irene M. Estores. 2019. « Hormonal Regulation In Pcos Using Acupuncture And Herbal Supplements: A Case Report And Review Of The Literature ». Integrative Medicine: A Clinician's Journal 18 (5): 36‑39.

[9] Ibrahim, N. A., A. S. Shalaby, R. S. Farag, G. S. Elbaroty, S. M. Nofal, et E. M. Hassan. 2008. « Gynecological efficacy and chemical investigation of Vitex agnus-castus L. fruits growing in Egypt ». Natural Product Research 22 (6): 537‑46.

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