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Le seed cycling : la solution pour réguler son cycle ?

Seed cycling: the solution for regulating your cycle?

Seed syncing, or seed synchronisation, is a naturopathic practice based on the various properties of seeds — in particular their potential benefits for hormonal imbalances.
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Take care mama

Have you just stopped taking the pill? Are you in the postpartum period? Or do you simply want a regular cycle? Try seed cycling — a blend of seeds designed to help regulate your cycle. Beyond its effects on the cycle, seeds are packed with beneficial nutrients for your overall health.

The menstrual cycle

The menstrual cycle is divided into two phases, separated by ovulation:
 

The follicular phase

The follicular phase runs from day 1 of the cycle through to ovulation.

Under the action of follicle-stimulating hormone (FSH), oestrogen levels rise progressively from the first day of menstruation. Oestrogens support follicle maturation and endometrial growth. At the time of ovulation, oestrogen levels are at their peak, indicating that the follicle is mature. Luteinising hormone (LH) is then secreted. 
 

The luteal phase

The second phase of the cycle begins under the effect of LH and corresponds to the luteal phase. What remains in the follicle transforms into the corpus luteum, which secretes oestrogen and the hormone progesterone, which supports the implantation of the embryo in the endometrium of the uterus to initiate pregnancy.

If fertilisation does not occur, the corpus luteum degenerates, leading to a cessation of oestrogen and progesterone secretion. This hormonal drop triggers a new cycle with the onset of menstruation [1]. 

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How important is hormonal balance for the menstrual cycle?

Hormonal balance means the right hormones being secreted at the right time, in harmony. 
 

Our hormones, whether sexual or otherwise, all work in synergy. Just as in nature, if a species disappears or spring arrives too early it has consequences for the entire ecosystem, in our bodies if a hormone is secreted too much, too little, or at the wrong time, all the others are affected. 
 

So, when there is too much or too little oestrogen, this affects not only ovulation, endometrial quality and periods, but also the production of progesterone for example, of histamine (an inflammatory substance involved in gastric acid secretion, allergies, headaches, skin concerns…), bone health, brain health, muscle health, and liver function… 

Did you know?

Flaxseeds contain lignans, which help balance oestrogen levels in the body!

Excess oestrogen contributes to heavy periods, menstrual pain, breast pain [2], endometriosis, fibroids, premenstrual syndrome, and hormone-dependent cancers such as certain types of breast cancer [3]. 

Without sufficient oestrogen, the endometrium grows very little, and periods are consequently lighter and/or shorter. This can lead to fertility problems, as the quality and thickness of the endometrium are crucial factors in successful embryo implantation. Finally, given the impact of oestrogens on our mood, brain, libido, memory and sleep, a lack of oestrogen can also manifest through the following symptoms: memory loss, depression, anxiety, lethargy, night waking, reduced libido, vaginal dryness…

Insufficiently robust progesterone is problematic for fertility. In this case, the luteal phase (and therefore the time available for the embryo to implant in the endometrium) is shortened. Progesterone deficiency is also often at the root of miscarriages. Low progesterone production can also lead to the symptoms of premenstrual syndrome. 

Hence the importance of regulating our hormones — both for our gynaecological and reproductive health, and for our overall wellbeing!

A few tips

Seeds are not magic — it is important to also follow a suitable diet alongside them (free from refined sugars, processed and inflammatory foods, but rich in healthy fats and essential nutrients).

What is the principle behind seed cycling?

Seed cycling is a nutritional practice that aims to support and improve the menstrual cycle by recommending the consumption of four specific seeds.

By selecting specific seeds, seed cycling aims to rebalance hormone levels and thus help prevent the discomforts associated with the menstrual cycle by acting on both of the phases mentioned.
 

Seed cycling may help in the management of Premenstrual Syndrome (PMS), which is often a sign of fluctuating circulating levels of oestrogen and progesterone hormones. 

It may also be indicated in polycystic ovary syndrome (PCOS), endometriosis, and infertility, as well as to help alleviate symptoms such as hot flushes, night sweats, fatigue, and mood swings [4]. 

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Seed cycling during the follicular phase

Seed cycling begins on the first day of your period.

During the follicular phase, the phytoestrogens found in flaxseeds may help to regulate oestrogen levels. Zinc found in pumpkin seeds may help to support progesterone production in preparation for the next phase of the cycle.

Flaxseeds are one of the best sources of lignans, a type of phytoestrogen. Plant-based phytoestrogens are 100 to 1,000 times weaker than oestrogens, but they help maintain hormonal balance by exerting an anti-oestrogenic or oestrogenic effect depending on whether levels are respectively too high or too low.

They bind weakly and temporarily to oestrogen receptors, allowing the body to eliminate excess oestrogens, or they act directly on the pituitary gland or even on other glands.

These lignans thus increase the presence of Sex Hormone Binding Globulin (SHBG), a protein produced by the liver that plays a major role in the metabolism and excretion of oestrogens. By supporting the liver's metabolism of oestrogens, the lignans in flaxseeds help to reduce excess oestrogens in the body [5].

A study found that daily ingestion of flaxseeds over three months may lead to a significant reduction in the number of ovarian cysts, as well as ovary size in women with PCOS. The same study also showed that flaxseed supplementation resulted in regular menstruation in 33% of women in the study cohort who previously had irregular cycles [6]. 

Flaxseeds are rich in magnesium (372 mg/100g), as are pumpkin seeds (535 mg/100g).

Magnesium plays a key role in hormonal balance, as it is essential for liver function and helps regulate our hormones: progesterone, oestrogen and testosterone. It also regulates cortisol, the stress hormone. It is equally important for the adrenal glands and the regulation of blood sugar levels/metabolism.

Most people do not consume enough magnesium-rich foods, and with stress, reserves are quickly depleted. Our bodies use up all their magnesium when we are stressed, not to mention that soil depletion makes it increasingly difficult to obtain through diet alone.

Some studies have shown that magnesium may lead to a significant reduction in the intensity and duration of premenstrual syndrome (mood changes, anxiety, depression, bloating, breast pain, water retention…). [7] 

Flaxseeds are also an excellent source of vitamin B1 (1.22 mg/100g), also known as thiamine, which contributes to a significant reduction in menstrual cramps, particularly in those suffering from dysmenorrhoea (pain occurring during menstruation) [8]. Research has indicated that women with a high dietary intake of thiamine present a notably lower risk of PMS. Thiamine is particularly effective at reducing depression and cramps associated with PMS [9].

Pumpkin seeds are an excellent source of zinc (7.5 mg/100g), a nutrient necessary for ovulation that helps stimulate follicles and the release of the LH hormone. It also plays a role in increasing progesterone levels as well as the production of FSH, which helps prepare the body for ovulation. 

Studies show that zinc supplementation has anti-inflammatory effects. By reducing inflammation and allowing better oxygen flow to the uterus, zinc can counteract the effects of prostaglandins and reduce both the incidence and duration of painful menstrual cramps. Research also shows that zinc reduces the severity of menstrual bleeding [10].

Furthermore, seeds contain a lot of fibre, which can help bind and eliminate toxins and hormones from the digestive tract, as well as regulate insulin. 

 The benefits of fibre are numerous:

They play a prebiotic role: fibres such as those from flaxseed (lignans) are often converted by gut bacteria into protective phyto-oestrogens.

Fibre is the food of the "good bacteria" in the gut microbiome. By consuming plenty of it — and in varied forms — we prevent the "good" bacteria from literally starving and the "bad" bacteria from taking their place, proliferating and disrupting several factors including hormonal regulation. Microbiome balance is also important in the detoxification of oestrogens, as they are excreted via stools. If the gut flora is imbalanced, certain bacteria could prevent the excretion of oestrogens, causing a surplus of them. Bad bacteria release an enzyme called beta-glucuronidase, which prevents the elimination of oestrogens via stools and causes them to recirculate in the blood, thereby contributing to an excess of oestrogens. 

They also act as a "broom" in the intestines, helping to move intestinal contents along and thereby regulate transit, facilitating the elimination of toxins and oestrogens.

Flaxseeds and pumpkin seeds contain high levels of fatty acids that help regulate FSH levels, reduce inflammation and support the production of sex hormones [11]. 

The conversion of linoleic acid from these seeds into other essential fatty acids contributes to the production of prostaglandins, which are essential for ovulation. A disruption in prostaglandin metabolism may be one cause of PMS symptoms [12]. Taking this seed blend may therefore help improve prostaglandin levels and thus have an effect on PMS and painful periods [13] [12].

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Seed cycling: the solution for regulating your cycle?

To stock up on nutrients, you can combine this practice with taking a food supplement to support conception multivitamin, for example.

Seed cycling during the luteal phase

It begins on the day of ovulation.

This second phase involves consuming sunflower and sesame seeds during the luteal phase to block excess oestrogen and stimulate progesterone production with the vitamin E found in sunflower seeds [14].

Sesame seeds are rich in lignans, and we have seen the many beneficial effects of these compounds. 

Zinc helps reduce inflammation during this phase and prepares the body for future menstruation. Sunflower seeds are a good source of zinc (4 mg/100g) and magnesium (325 mg/100g). Together with magnesium, it also acts to help prevent symptoms that appear before a period.

Sesame seeds also contain vitamin B6 (0.8 mg/100 g). This vitamin may act on symptoms such as anxiety, irritability, and premenstrual nervous tension [15].

High levels of oestrogen in the blood and low levels of progesterone have been observed in groups experiencing these symptoms. Vitamin B6 may reduce blood oestrogen, increase progesterone, and lead to an improvement in symptoms. 

The action of this vitamin goes even further. Indeed, it helps to lower levels of the hormone aldosterone. In excess, this hormone can cause symptoms such as water and salt retention, abdominal bloating, mastalgia, and weight gain. By reducing levels of this hormone, vitamin B6 may help to improve these symptoms [16].

Sunflower seeds contain vitamin E (33 mg/100g), which has a significant effect on your cycle. Indeed, studies have shown that it improves ovulation and progesterone production. It may help reduce the severity of dysmenorrhoea by decreasing the pain associated with menstruation [17]. 

Seeds are also rich in fatty acids, particularly polyunsaturated ones such as omega-3. One study showed that co-supplementation with omega-3 and vitamin E led to significant improvements in scores related to depression, anxiety and stress.

Our pregnancy omega-3, Omega Mama, is perfectly suited to all women, pregnant or not. It helps to meet women's needs.

Sunflower seeds are rich in selenium, which supports the liver's detoxification of hormones [18].

Furthermore, in one study, patients with PCOS who received selenium supplements showed significantly reduced serum levels of dehydroepiandrosterone (DHEA, a pro-hormone involved in the synthesis of androgens and oestrogens [19]), and significantly reduced hirsutism [20].

These nutrients may also have an effect on hormones. Indeed, a supplementation study involving various nutrients including vitamin E and selenium showed that this intake led to a significant reduction in the LH/FSH ratio and testosterone levels in women with PCOS [21].

To stock up on nutrients, discover our range of women's food supplement, with magnesium, omega-3s, iron, and more. 

How to practise seed cycling in your daily life?

Start practising seed cycling based on your cycle, beginning on the first day of your period. 

Phase 1 (Pumpkin seeds and flaxseeds): from the first day of your period until ovulation

Phase 2 (Sunflower seeds and sesame seeds): from ovulation until your next period 

In theory, ovulation occurs in the middle of the cycle. For people with a 28-day cycle, ovulation generally takes place on day 14 (the first day of the cycle corresponds to the first day of the period).

However, many women do not have a 28-day cycle or do not have regular cycles. As a general rule, each woman tends to have a luteal phase that lasts roughly the same number of days (typically 10 to 14 days), and it is the length of the follicular phase that tends to vary. On average, therefore, ovulation occurs 10 to 14 days before the period.
 

To calculate your cycle, check out our article on how to calculate your ovulation.

No need to stress about the days!

"While these seeds may have an effect on each stage of the cycle, the body actually needs more time to adjust — and it takes what it needs according to the requirements of each phase. Rather than talking about 'cycling', it would be more accurate to talk about nutritional support. Eating sesame/flaxseeds in the first half of the cycle will of course not cause any hormonal imbalance, and will also be beneficial in the second half, as the body stores them for use according to its needs." (Alix d'Antras, naturopath)

Seed cycling should of course not replace a healthy lifestyle!

A healthy and varied diet.
Physical exercise.
Stress management.
And avoid environmental toxins and endocrine disruptors.

The effects of seed cycling may appear after several months. It can be helpful to keep notes in a journal to track the improvements observed!

You can consume a tablespoon of flaxseeds and pumpkin seeds for the first phase, and a tablespoon of sesame seeds and sunflower seeds for the second.

You can grind these seeds and add them to your drinks. This is a viable option — not too complicated if you have something to grind them with — but not very easy to store due to oxidation, and frankly not very tasty!

Seed cycling can also support women during perimenopause, when the cycle becomes irregular. For more targeted support at this stage, you can explore our menopause supplements.

Conclusion: the benefits of seed cycling

The benefits of seed cycling are unfortunately still not well studied. 
 

However, a number of studies have been conducted on the various seeds used in this practice. 
 

Furthermore, seeds have benefits beyond the menstrual cycle. For example, a mixture of flaxseeds and pumpkin seeds added to the diet may be useful in preventing complications of diabetes [22]. 

Thanks to their richness in micronutrients, the consumption of flaxseeds, sesame seeds and sunflower seeds has been associated with an improvement in risk factors for heart disease, such as high cholesterol and blood pressure. 

Furthermore, according to some studies, flaxseeds may offer protection against breast cancer, notably thanks to their lignin content [23] and also their omega-3 content [24]. 
 

That said, be patient — your body will need time to regulate itself and find its balance again!
 

Be careful not to self-supplement — food supplements are not without risk; they can interact with other supplements, foods and medications, and may not be suited to your personal situation, not to mention that choosing the right ones and adapting the dosages requires care. It is therefore preferable to seek advice from a healthcare practitioner specialising in nutrition (such as a naturopath or nutritional therapist).

Source 1 : Basics of the Menstrual Cycle – Your Period

Source 2 : Factors Effecting Mastalgia, 2016

Source 3 : Breast pain - Women's health problems, MSD Manuals for the general public

Source 4 : What Is Seed Cycling? Effects on Hormones and Menopause, Healthline, 2019

Source 5 : Effect of Dietary Components, Including Lignans and Phytoestrogens, on Enterohepatic Circulation and Liver Metabolism of Estrogens and on Sex Hormone Binding Globulin (SHBG), 1987

Source 6 : Effects of Flax Seeds Supplementation in Polycystic Ovarian Syndrome, 2015

Source 7 : Magnesium supplementation alleviates premenstrual symptoms of fluid retention, 1998

Source 8 : What Is Seed Cycling? Effects on Hormones and Menopause, Healthline, 2019

Source 9 : The effects of vitamin B1 on ameliorating mental symptoms of premenstrual syndrome, Abdollahifard S, Maddahfar M, 2016

Source 10 : Zinc treatment prevents dysmenorrhea, 2007

Source 11: Seed Cycling and Moon Syncing - What to Know about Syncing Your Hormones, Omne Wellness

Source 12 : Prostaglandins and premenstrual syndrome, 1992

Source 13 : Supplementation with omega-3 polyunsaturated fatty acids in the management of dysmenorrhea in adolescents, 1996

Source 14 : Does Seed Cycling Help Balance Hormones?, Reinagel, Nutrition Diva Monica, Scientific American

Source 15, 16 : Nutritional factors in the etiology of the premenstrual tension syndromes, Abraham GE, 1983

Source 17 : Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea, Pakniat H, et al., 2019

Source 18 : Can Seed Cycling Ease Menstrual Cycle Complications and Symptoms? – DUTCH Test

Source 19 : Update on dehydroepiandrosterone (DHEA), Netgen, Swiss Medical Review

Source 20 : Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome, Razavi M, et al., 2016

Source 21 : The impact of a standardized micronutrient supplementation on PCOS-typical parameters, Hager M, et al., 2019

Source 22 : Antidiabetic Effect of Flax and Pumpkin Seed Mixture Powder, Makni M, et al., 2011

Source 23 : Dietary Flaxseed Inhibits Human Breast Cancer Growth and Metastasis, 2002

Source 24 : The Effect of Flaxseed in Breast Cancer: A Literature Review, Calado A, et al., 2018

[1] « Basics of the Menstrual Cycle – Your Period ». n.d.. https://www.yourperiod.ca/fr/normal-periods/menstrual-cycle-basics/#cycleComprehensive.

[2] Eren T, Aslan A, Ozemir IA, Baysal H, Sagiroglu J, Ekinci O, Alimoglu O. Factors Effecting Mastalgia. Breast Care (Basel). 2016 Jun;11(3):188-93. doi: 10.1159/000444359. Epub 2016 Mar 29. PMID: 27493619; PMCID: PMC4960349. 10.1159/000444359

[3] « Breast Pain - Women's Health Issues ». n.d. MSD Manuals for the general public. Accessed 13 April 2021.
https://www.merckmanuals.com/fr-ca/accueil/probl%C3%A8mes-de-sant%C3%A9-de-la-femme/maladies-du-sein/douleur-mammai e.

[4] « What Is Seed Cycling? Effects on Hormones and Menopause ». 2019. Healthline. 18 July 2019.
https://www.healthline.com/nutrition/seed-cycling.

[5] Adlercreutz H, Hockerstedt K, Bannwart C, et al. Effect of Dietary Components, Including Lignans and Phytoestrogens, on Enterohepatic Circulation and Liver Metabolism of Estrogens and on Sex Hormone Binding Globulin (SHBG). Journal of Steroid Biochemistry. 1987; 27 (4–6): 1135–1144. doi: 10.1016/0022-4731 (87)90200-7. 10.1016/0022-4731(87)90200-7

[6] Fatima Farzana K, et al. Effects of Flax Seeds Supplementation in Polycystic Ovarian Syndrome. International Journal of Pharmaceutical Sciences Review and Research. 2015;31(1), 113–119.

[7] Walker AF, Souza MCD, Vickers MF, Abeyasekera S, Collins ML, and Trinca LA. Magnesium supplementation alleviaes premenstrual symptoms of fluid retention. Journal of Women's Health. 1998;7(9):1157-1165. doi: 10.1089/jwh.1998.7.1157. 10.1089/jwh.1998.7.1157

[8] « What Is Seed Cycling? Effects on Hormones and Menopause ». 2019. Healthline. 18 July 2019. https://www.healthline.com/nutrition/seed-cycling.

[9] Abdollahifard S, Maddahfar M. The effects of vitamin B1 on ameliorating of mental symptoms of the premenstrual syndrome. European Psychiatry. 2016;33:s335. doi:10.1016/j.eurpsy.2016.01.745. 10.5539/gjhs.v6n6p144

[10] Eby GA. Zinc treatment prevents dysmenorrhea. Medical hypotheses. 2007;69(2):297-301. doi: 10.1016/j.mehy.2006.12.009. 10.1016/j.mehy.2006.12.009

[11] « Seed Cycling and Moon Syncing - What to Know about Syncing Your Hormones ». n.d. Omne Wellness. https://www.omnewellness.com/blog/menstrualcycle.

[12] Koshikawa N, Tatsunuma T, Furuya K, Seki K. Prostaglandins and premenstrual syndrome. Prostaglandins Leukot Essent Fatty Acids. 1992 Jan;45(1):33-6. doi: 10.1016/0952-3278(92)90099-5. PMID: 1546064. 10.1016/0952-3278(92)90099-5

[13] Harel, Z., et al., Supplementation with omega-3 polyunsaturated fatty acids in the management of dysmenorrhea in adolescents. Am J Obstet Gynecol, 1996. 174(4): p. 1335-8. 10.1016/s0002-9378(96)70681-6

[14] Reinagel, Nutrition Diva Monica. n.d. « Does Seed Cycling Help Balance Hormones? » Scientific American. https://www.scientificamerican.com/article/does-seed-cycling-help-balance-hormones/.

[15] Abraham GE. Nutritional factors in the etiology of the premenstrual tension syndromes. J Reprod Med. 1983 Jul;28(7):446-64. PMID: 6684167.

[16] Abraham GE. Nutritional factors in the etiology of the premenstrual tension syndromes. J Reprod Med. 1983 Jul;28(7):446-64. PMID: 6684167.

[17] Pakniat, Hamideh, Venus Chegini, Fatemeh Ranjkesh, et Mohammad Ali Hosseini. 2019. « Comparison of the effect of vitamin E, vitamin D and ginger on the severity of primary dysmenorrhea: a single-blind clinical trial ». Obstetrics & Gynecology Science 62 (6): 462‑68. https://doi.org/10.5468/ogs.2019.62.6.462

[18] « Can Seed Cycling Ease Menstrual Cycle Complications and Symptoms? – DUTCH Test ». n.d. https://dutchtest.com/2020/07/20/seed-cycling/.

[19] Netgen. n.d. « Update on dehydroepiandrosterone (DHEA) ». Revue Médicale Suisse. https://www.revmed.ch/RMS/2005/RMS-6/30132.

[20] Razavi, M., M. Jamilian, Z. Fakhrieh Kashan, Z. Heidar, M. Mohseni, Y. Ghandi, T. Bagherian, et Z. Asemi. 2016. « Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome ». Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme 48 (3): 185‑90. https://doi.org/10.1055/s-0035-1559604.

[21] Hager, Marlene, Kazem Nouri, Martin Imhof, Christian Egarter, et Johannes Ott. 2019. « The impact of a standardized micronutrient supplementation on PCOS-typical parameters: a randomized controlled trial ». Archives of Gynecology and Obstetrics 300 (2): 455‑60. https://doi.org/10.1007/s00404-019-05194-w.

[22] Makni, Mohamed, Hamadi Fetoui, Nabil K. Gargouri, El Mouldi Garoui, et Najiba Zeghal. 2011. « Antidiabetic Effect of Flax and Pumpkin Seed Mixture Powder: Effect on Hyperlipidemia and Antioxidant Status in Alloxan Diabetic Rats ». Journal of Diabetes and Its Complications 25 (5): 339‑45. https://doi.org/10.1016/j.jdiacomp.2010.09.001.

[23] Chen J, Stavro PM, &Thompson LU. Dietary Flaxseed Inhibits Human Breast Cancer Growth and Metastasis and Downregulates Expression of Insulin-Like Growth Factor and Epidermal Growth Factor Receptor. Nutrition and Cancer. 2002;43(2): 187-192. doi: 10.1207/s15327914nc432_9. 10.1207/S15327914NC432_9

[24] Calado, Ana, Pedro Miguel Neves, Teresa Santos, et Paula Ravasco. 2018. « The Effect of Flaxseed in Breast Cancer: A Literature Review ». Frontiers in Nutrition 5 (février). https://doi.org/10.3389/fnut.2018.00004.

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