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Optimiser sa fertilité lorsque l’on souffre du syndrome des ovaires polykystiques

Optimising your fertility when living with polycystic ovary syndrome

Are you living with polycystic ovary syndrome and wondering about your ability to conceive? We tell you everything!
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Do you have polycystic ovary syndrome and are wondering about your ability to conceive?
Rest assured… PCOS is not a diagnosis of infertility, and the vast majority of women who have it will be able to fulfil their plans to have a baby, with or without medical assistance.
We shed light on how polycystic ovary syndrome may impact your fertility, as well as the natural solutions that can help support PCOS and pregnancy.

Take care mama

Adopting a diet aimed at reversing PCOS symptoms involves avoiding pro-inflammatory foods such as sugar and processed foods, and optimising meal timing to allow blood sugar levels to rise and then fall gradually.

What is polycystic ovary syndrome?

Polycystic ovary syndrome, or Stein-Leventhal syndrome, is a condition of the endocrine system defined as a cluster of symptoms linked to anovulatory menstrual cycles (absence of ovulation) and elevated levels of androgens (male hormones).


The main symptoms of PCOS include absent or irregular periods, weight gain, excessive facial and body hair (hirsutism), persistent adult acne, hair loss, and depression. 

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What are the impacts of PCOS on the ability to conceive?

PCOS is the leading cause of female infertility. Statistically, women with this condition will take longer to get a positive pregnancy test


Indeed, polycystic ovary syndrome is behind several issues that affect the chances of conceiving a baby.

Did you know?

Exercise can prove to be a valuable ally in supporting your fertility. Physical activity can help make muscle cells more sensitive to insulin. And the more sensitive cells are to insulin, the better the hormonal balance!

A woman with PCOS ovulates less frequently than a woman without the condition, and therefore has fewer chances of conceiving naturally.
In other words, in the vast majority of cases, the aim will be to restore regular ovulatory cycles.

Even when ovulatory cycles have been restored, scientific studies show that women with PCOS produce lower-quality eggs than women without the condition[1]. This appears to be due to an intrinsic defect in the egg itself, as well as excess androgens in the ovary[2].

This lower egg quality can complicate the implantation of the fertilised egg in the uterine cavity and increase the risk of miscarriage. It is also possible to have a ovarian reserve low. This condition is notably affected by stress, inflammation, etc. — many factors found in PCOS. 

Being overweight or obese, which affects a large proportion of women with PCOS, can also contribute to it taking longer to conceive.

It has been shown, for example, that the metabolic dysfunctions associated with PCOS can affect the ability of the endometrium to receive the fertilised egg and therefore the implantation stage[3].

Our food supplement to help conceive Ovo+ is suitable in cases of PCOS. It supports, in particular: egg quality, healthy ovulation and fertility. 

What are the main medical treatments for PCOS-related infertility?

To date, there is no medical treatment for polycystic ovary syndrome; medical management is limited to relieving its symptoms.


Here is an overview of the main medical treatments that may be offered to you to treat infertility related to PCOS.

The first options you will generally be offered are metformin and clomiphene citrate (more commonly known as Clomid).

By improving insulin sensitivity, metformin may help to restore ovulation. However, leading scientific experts now advise against its use as a first-line treatment due to its limited effects on treating infertility[4]. 

As for Clomid, its function is to trigger ovulation. The pregnancy rate achieved is approximately 25%[5].

When these first-line therapies have not been successful, it is generally recommended to move on to injectable hormones to induce ovulation, combined with intrauterine insemination (also known as artificial insemination) or in vitro fertilisation.

Sometimes, depending on your specific situation or age, you may be advised to move directly to artificial insemination or even in vitro fertilisation (IVF).

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How to improve your chances of pregnancy with PCOS?

Most women with PCOS will have as many children as other women[6].


There are indeed many reasons to be optimistic about your chances of realising your dreams of motherhood, with or without the help of medical assistance.
 

Once we recognise that certain factors can affect our fertility, we can indeed take action to reverse the trend.
 

In general, lifestyle, environment and physical exercise are three major factors in a woman's ability to conceive with PCOS.
 

Here is an overview of the levers you can activate to maximise your fertility:
 

Build your medical team
 

Having the right people supporting you is essential, both for the success of your baby project and (above all) for your long-term health.
Here is a (non-exhaustive) list of people to consider including in your team:
GP (GENERAL PRACTITIONER): Having a "family doctor" on your team who will follow you throughout your journey and act as coordinator of your care pathway is essential.
ENDOCRINOLOGIST: A specialist doctor in hormones and the endocrine system. They will be particularly important in cases of diabetes or thyroid dysfunction.
GYNAECOLOGIST: A specialist doctor in the female reproductive system. Consulting one is important whether or not you are trying to conceive.
FUNCTIONAL MEDICINE: Functional medicine takes a whole-person approach to the patient. It will consider your metabolic system, your adrenal glands and all the other drivers at work in your condition.
NATUROPATH: A naturopath will approach your PCOS from a holistic perspective. This takes the individual as a whole and their environment into consideration. They will seek to address the root cause of your symptoms.
ACUPUNCTURIST: Scientific studies suggest that acupuncture improves IVF success rates. Others show that acupuncture can improve the clinical symptoms of PCOS, sex hormone levels and the menstrual cycle in patients.
OSTEOPATH: An osteopath can help release tensions accumulated in different areas of the body that may be interfering with healthy hormonal function, or work more specifically on the hormonal glands.
DIETITIAN NUTRITIONIST: These healthcare professionals can help you implement the changes needed to regulate your hormones. They can also guide you in establishing new dietary habits.

Do not hesitate to foster a collaborative spirit among the different members of your team.

Learn to understand your cycle
 

PCOS is characterised by irregular or absent cycles.
 

It is therefore essential to be able to know and understand your cycles in order to maximise your chances of conceiving, and also to share this information with your doctor. Knowing how calculate your ovulation can be a good starting point. 
 

Get a full hormonal assessment


In order to determine the changes to make to your lifestyle or diet, you will need to know your hormone levels at the different phases of your cycle.


Key hormones affecting our ovulatory cycle, our fertility, our thyroid and our weight:
Oestradiol
Progesterone
Luteinising hormone (LH)
FSH (follicle-stimulating hormone)
DHEA (dehydroepiandrosterone)
Testosterone
Cortisol
TSH
T3
T4
Anti-thyroglobulin antibodies


A diet tailored to your condition 

The key takeaway is that improving diet and lifestyle makes a successful pregnancy significantly more likely when fertility treatments are subsequently undertaken[7].


Adopting a diet designed to help reverse the symptoms of PCOS involves avoiding pro-inflammatory foods such as sugar or processed foods, and optimising food intake to allow blood sugar levels to rise and then fall slowly.
 

Such adjustments to your diet may help improve your insulin response and activate mechanisms that can support the management of infertility related to polycystic ovary syndrome.
 

Furthermore, working on your diet can also increase your chances of a lower-risk pregnancy by helping to avoid miscarriage, gestational diabetes and pre-eclampsia.
 

Women with PCOS often have a complicated relationship with food and their body. The aim is therefore to adjust your diet in a way that encourages the right responses from your body, with no restrictive logic whatsoever. 
 

Taking food supplements

A dietary therapy approach may also include the use of a pcos supplement. Some have been shown to be particularly effective in addressing the symptoms of PCOS that contribute to infertility*.
 

As an example, the myo-inositol powder is a safe and affordable supplement that has already been widely proven, as it may increase egg quality and reduce the risk of ovarian hyperstimulation during IVF[8]. A supplement inositol pcos can therefore help. Our article inositol benefits explains in detail how it can help. 

Taking prenatal vitamins can help meet your nutritional needs. Takingomega 3 pregnancy, such as DHA, would also be beneficial according to studies. 
 

Look after your gut


If you regularly suffer from bloating, abdominal pain, gas or diarrhoea, or if you have been diagnosed with a condition such as irritable bowel syndrome or inflammatory bowel disease (such as Crohn's disease), your fertility is very likely to be affected.


Your digestive health can be supported by a diet rich in prebiotics, which help nourish the beneficial gut bacteria, and probiotics. You can find prebiotics in a wide range of foods such as garlic, onion, artichoke, parsnip, asparagus, cabbage, berries, certain legumes (lentils, chickpeas) and certain nuts and seeds (almonds, pistachios, walnuts). Probiotics, meanwhile, are found in fermented foods such as kefir, kombucha, or raw sauerkraut.
 

Avoiding foods known to be inflammatory, such as sugar, vegetable oils, gluten and dairy products, can also help support gut health.
 

Keep moving
 

Exercise can prove to be a valuable ally in supporting your fertility.
Physical exercise helps make muscle cells more sensitive to insulin. The more sensitive cells are to insulin, the better the hormonal balance.


For example, progressive strength training sessions may help reduce insulin resistance[9] as well as lower free androgen levels[10]. The effect of exercise on these mechanisms can in turn support ovarian function and, therefore, fertility.
 

Furthermore, exercise has a beneficial effect on inflammation[11], which is one of the other main causes of PCOS.
 

Long-endurance forms of physical activity such as running should be avoided, as they tend to increase cortisol (the stress hormone). Prolonged elevated cortisol levels can impair the immune system, worsen insulin resistance and increase the overproduction of androgenic hormones.
 

It is also worth combining more intense forms of physical activity with gentler exercises, such as yoga, dancing or walking.


Be mindful of your environmental health
 

The products and substances that surround us in daily life are just as important as the foods we consume.


Most conventional cleaning and personal care products contain endocrine disruptors and harmful chemicals capable of mimicking oestrogens in our bodies. These substances have a direct impact on our hormonal system and our fertility.
 

The aim here is to gradually reduce your toxic load, allowing your body to strengthen its detoxification functions, which will in turn support your fertility.
 

Learn to manage your stress

When faced with a stressful situation, women with PCOS show particularly high cortisol levels. The risk of infertility is twice as high in women with the highest biological markers of stress[12].


Women with PCOS often have to juggle numerous medical appointments. On top of that, they may also be embarking on a assisted reproduction pathway that she will need to fit in alongside an already busy professional and personal life.


It will be worth choosing the stress-reduction technique or techniques that suit you best and that are easiest to incorporate into your daily life.
 

Among the most common are meditation and relaxation, yoga, heart coherence exercises and walking.
 

Make yourself your priority

This recommendation may seem like the most obvious one, yet it is also the most important: take care of yourself.
None of the changes you make to your diet or lifestyle will be truly effective if you do not also learn to take care of yourself.
Your fertility is directly linked to your emotional and physical wellbeing.

Preserving your fertility: the scientific guide to egg quality

An ebook comprehensive to understand the mechanisms that influence egg quality.
Discover the causes of egg quality decline and the science-backed levers (nutrition, supplements, lifestyle) to start acting on your fertility right now.

Optimising your fertility when living with polycystic ovary syndrome

Conclusion

The key thing to remember is that a successful pregnancy is possible when you have PCOS. By focusing on ways to maximise your fertility, you give yourself every chance of making your dream of motherhood a reality.


*Please do not self-supplement without the advice of a qualified healthcare practitioner. This information does not replace the advice of a doctor or any ongoing medical treatment. Do not hesitate to speak to your gynaecologist. 

[1] Palomba Stefano, Daolio Jessica, La Sala Giovanni, 2016/12/01, Oocyte Competence in Women with Polycystic Ovary Syndrome, vol. 28, 10.1016/j.tem.2016.11.008, Trends in Endocrinology & Metabolism.

[2] Patel SS, Carr BR. Oocyte quality in adult polycystic ovary syndrome. Semin Reprod Med. 2008 Mar;26(2):196-203. doi: 10.1055/s-2008-1042958. PMID: 18302111.

[3] Schulte MM, Tsai JH, Moley KH. Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation. Reprod Sci. 2015 Jan;22(1):6-14. doi: 10.1177/1933719114561552. Epub 2014 Dec 7. PMID: 25488942; PMCID: PMC4275454.

[4] Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK; Endocrine Society. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013 Dec;98(12):4565-92. doi: 10.1210/jc.2013-2350. Epub 2013 Oct 22. Erratum in: J Clin Endocrinol Metab. 2021 May 13;106(6):e2462. PMID: 24151290; PMCID: PMC5399492.

[5] Homburg R. Clomiphene citrate--end of an era? A mini-review. Hum Reprod. 2005 Aug;20(8):2043-51. doi: 10.1093/humrep/dei042. Epub 2005 May 5. PMID: 15878925.

[6] Persson S, Elenis E, Turkmen S, Kramer MS, Yong EL, Sundström-Poromaa I. Fecundity among women with polycystic ovary syndrome (PCOS)-a population-based study. Hum Reprod. 2019 Oct 2;34(10):2052-2060. doi: 10.1093/humrep/dez159. PMID: 31504532.

[7] Legro RS, Dodson WC, Kunselman AR, et al. Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS. J Clin Endocrinol Metab. 2016;101(7):2658-2666. doi:10.1210/jc.2016-1659

[8] Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino F. Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial. Eur Rev Med Pharmacol Sci. 2011 May;15(5):509-14. PMID: 21744744.

[9] Cheema BS, Vizza L, Swaraj S. Progressive resistance training in polycystic ovary syndrome: can pumping iron improve clinical outcomes? Sports Med. 2014 Sep;44(9):1197-207. doi: 10.1007/s40279-014-0206-6. PMID: 24872311.

[10] Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD. The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008 Sep;93(9):3373-80. doi: 10.1210/jc.2008-0751. Epub 2008 Jun 26. PMID: 18583464.

[11] Covington JD, Tam CS, Pasarica M, Redman LM. Higher circulating leukocytes in women with PCOS is reversed by aerobic exercise. Biochimie. 2016;124:27-33. doi:10.1016/j.biochi.2014.10.028

[12] Lynch CD, Sundaram R, Maisog JM, Sweeney AM, Buck Louis GM. Preconception stress increases the risk of infertility: results from a couple-based prospective cohort study--the LIFE study. Hum Reprod. 2014 May;29(5):1067-75. doi: 10.1093/humrep/deu032. Epub 2014 Mar 23. PMID: 24664130; PMCID: PMC3984126

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